reverse transcriptase-in-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12715	Reverse transcriptase-IN-1		HIV Protease
	Reverse transcriptase-IN-1 is a diarylbenzopyrimidine (DABP) analogue and a potent inhibitor of HIV-1 nonnucleoside reverse transcriptase with an IC50of 13.7 nM.		HIV Protease
T2330	Rilpivirine	TMC278,R278474,DB08864	HIV Protease , Reverse Transcriptase
	Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infections.		HIV Protease , Reverse Transcriptase
T3632	Doravirine	MK-1439	HIV Protease , Reverse Transcriptase
	Doravirine (MK-1439) is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.		HIV Protease , Reverse Transcriptase
T4S1718	Punicalin		HBV , HIV Protease
	Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg/ml (0.14 microM).		HBV , HIV Protease
T29037	UC-781	NSC 675186,UC781,UC 781	Antiviral , HIV Protease
	UC-781 (NSC-675186) is a potent and selective inhibitor of human immunodeficiency virus HIV-1 non-nucleoside reverse transcriptase (NNRTI) I with a C50 value of 5 nM.UC-781 exhibits both antiviral activity and drug resis...		Antiviral , HIV Protease
T0682	Lamivudine	GR109714X,BCH-189	HIV Protease , Reverse Transcriptase
	Lamivudine (BCH-189) is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.		HIV Protease , Reverse Transcriptase
T1595	Nevirapine	NSC 641530,BI-RG 587,NVP	HIV Protease , Reverse Transcriptase
	Nevirapine (NVP) is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral loads and increases CD4 counts, thereby retarding or preve...		HIV Protease , Reverse Transcriptase
T14313	Apricitabine	AVX754,SPD754	HIV Protease , DNA/RNA Synthesis
	Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β a...		HIV Protease , DNA/RNA Synthesis
T15776	Loviride	R 89439	Others
	Loviride is a non-nucleoside reverse transcriptase inhibitor (IC50: 0.3 µM). Loviride inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells. It is used for reverse transcriptase from HIV-1.		Others
T28811	SM111	SM 111,SM-111
	SM111 inhibits in vitro replication of HIV-1, including strains resistant to reverse transcriptase, licensed protease, and integrase inhibitors, without major cellular toxicity.
T72206	Reverse transcriptase-IN-4
	Reverse transcriptase-IN-4 is a potent, selective non-nucleoside reverse transcriptase (NNRT) inhibitor, demonstrating an EC50 of 0.053 μM against wild-type HIV-1 and 0.26 μM for the E138K HIV-1 mutant.
T72203	Reverse transcriptase-IN-3
	Reverse transcriptase-IN-3, a pyrimidine-5-carboxamide derivative, functions as an inhibitor of HIV-1, demonstrating potent activity against both wild-type and mutant strains of HIV-1.
T69382	INDOPY-1
	INDOPY-1 is a Nucleotide-Competing Reverse Transcriptase Inhibitor. INDOPY-1 was the first NcRTI discovered, displaying reversible competitive inhibition of dNTP binding. 3,4 Biochemical studies showed that INDOPY-1 arr...
T10141	4'-Ethynyl-2'-deoxyadenosine		Others
	4'-Ethynyl-2'-deoxyadenosine (4'-E-dA) is a nucleoside reverse transcriptase (RT) inhibitor. It is potent against drug-resistant HIV variants (EC50: 98 nM in MT-4 cells for anti-HIV-1 activity).		Others
T24839	Stampidine	HI-113,HI 113,HI113
	Stampidine can prevent the sexual transmission of HIV-1. It exhibited remarkable subnanomolar to low nanomolar in vitro antiretroviral potency against nucleoside reverse transcriptase inhibitor-resistant primary clinical...
T27442	GSK 224876	GSK-224876,GSK224876
	GSK 224876 is a novel next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI). It has activity against efavirenz-resistant strains in the treatment of treatment-naive HIV-1-infected subjects.
T61679	Abacavir monosulfate
	Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, a...
TN5243	Vitexilactone		NADPH-oxidase , HIV Protease , Antifection
	Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse transcriptase. It has trypanocidal activity, the minimum lethal ...		NADPH-oxidase , HIV Protease , Antifection
T26581	AIC-292
	AIC-292 is a potent reverse transcriptase inhibitor with well tolerated in different cell lines. In addition, activity of AIC292 could be demonstrated against a broad panel of wild-type HIV-1 group. AIC292 also retained ...
FL0097	Beta-L-D4A	2'3'-didehydro-2'3'-dideoxyadenosine
	beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor. The biological activity of beta-L-D4A is connected with the termination of the DNA chain synthesis in the 5'-3' direction.